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KMID : 1137020100210040269
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Journal of Gynecologic Oncology
2010 Volume.21 No. 4 p.269 ~ p.272
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Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients: a case report
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Chung Ye-Won
Bae Hyo-Sook
Han Song-I
Song Jae-Yoon
Kim In-Sun
Kang Jae-Seong
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Abstract
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Toremifene is an anti-estrogen which has been shown to be effective in the treatment of breast cancer, and is thought to be a less uterotrophic agent than tamoxifen. The risk assessment concerning endometrial cancer has been inconclusive because of its rare use up to the mid-1990s. We report a case of an adenosarcoma, which is a very rare type of uterine malignancy, after toremifene treatment for 5 years in a breast cancer patient. After 1 year of toremifene use, the patient had a benign Mullerian adenofibroma. After an additional 4 years of toremifene treatment, the endometrial polypoid lesion was transformed into a Mullerian adenosarcoma. Although toremifene is a promising anti-estrogenic agent in the treatment of breast cancer patients, clinicians should not neglect the possibility of a uterine malignancy.
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KEYWORD
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Toremifene, Tamoxifen, Mullerian adenosarcoma, Mullerian adenofibroma, Breast cancer
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